Mucoepidermoid carcinoma mec is one of the most common malignant neoplasms of the salivary glands in both pediatric and adult populations. Mucoepidermoid carcinoma mec comprises approximately 1015% of all salivary gland neoplasms and about 30% of salivary malignancies. Histocytologic grading of mucoepidermoid carcinoma of major. Fortythree consecutive cases of mucoepidermoid carcinoma of the major and minor salivary glands were studied to evaluate the influence of the following parameters on prognosis. Thus, the malignancy rate increases from 20% to 25% in the parotid gland to 40% to 50% in the submandibular gland and to 50% to 81% in the sublingual and minor salivary glands. The most common etiologic factor in the development of. Lowgrade mucoepidermoid carcinoma of the lacrimal gland in a. For accreditation purposes, this protocol should be used for the following procedures and tumor types. Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare morphological variant of thyroid carcinoma associated with hashimotos disease. The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. We describe the first case, to the best of our knowledge, of recurrent sclerosing mucoepidermoid carcinoma with eosinophilia in the minor salivary glands of the upper.
Nov 29, 2018 how is mucoepidermoid carcinoma of salivary gland treated. It can mimic most other tumors of the glands, and therefore is often considered in the differential. However, it can also occur in other organs including the salivary glands, particularly the parotid and submandibular glands. Prognostic nomograms for predicting overall survival and. Mucoepidermoid carcinoma of oral mucosa bmj case reports. Only in one case had a mucoepidermoid carcinoma developed in the wall o f a parotid duct cyst. The most common tumors of the salivary gland are pleomorphic adenomas, and the most frequent malignancy of the parotid gland is mucoepidermoid carcinoma. However it can present in the minor salivary glands, especially in the soft palate. Major salivary glands were involved in 46 cases 44 parotid, two submandibular, and intraoral minor glands in 23.
The tumors are formed by aggregates of squamous and mucin secretory cells and are classified histologically as high, intermediate, or low grade. Due to the rarity of these malignancies, various histologies, and wide ranging clinical behavior it has been difficult to standardize systemic therapy. The aim of this article is to report a case of mec in a 73yearsold male patient who presented with a painless firm fluctuant swelling in left preauricular area. Warthinlike mucoepidermoid carcinoma of the parotid gland. Synchronous mucoepidermoid carcinoma of tongue and. To date, only three such tumors have been reported in the minor salivary glands. The epithelial meta plasia and focal proli f erative activity in salivary duct cysts is comparable to similar alterations in odontogenic cysts as possible early manifestation o f a tumour, especially o f an ameloblastoma or mucoepidermoid carcinoma. Mucoepidermoid carcinoma is a common salivary tumor that affects both adults and children. Mucoepidermoid carcinoma of palatal minor salivary glands.
Considering the anatomical site, greater salivary glands, specially the parotid. Pdf mucoepidermoid carcinoma of the soft palate salivary. Mucoepidermoid carcinoma of the salivary glands in brazil. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Surgical treatment of the mucoepidermoid carcinoma of minor salivary gland origin is primarily a function of the anatomic site of the tumor and its histologic grade. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Prognostic factors in head and neck mucoepidermoid carcinoma.
Mucoepidermoid carcinoma has a predilection for adults in their fourth to sixth decades of life, without sex predilection. Minor salivary gland tumours account for 1015% of all salivary gland neoplasms and are usually malignant. Two types of tumors have been described under this category. Mucoepidermoid carcinoma is the most common type of malignancies originating from major salivary gland. Mucoepidermoid carcinoma mec is the most common malignant neoplasm of major and minor salivary glands and can also occur as an intraosseous tumor frequently called as central mec. Classification clinicalpathologic correlation, and results of treatment. Pdf mucoepidermoid carcinoma of minor salivary glands.
Pdf mucoepidermoid carcinoma of the soft palate salivary gland. Mucoepidermoid carcinoma is a rare primary thyroid tumor with indolent biologic potential. Mucoepidermoid carcinoma of the minor salivary gland. Cancer in the salivary gland is called salivary gland cancer. Mucoepidermoid carcinoma of the salivary gland sciencedirect. Treatment and survival outcomes based on histologic. In contrast to benign and lowgrade salivary gland neoplasms, which are managed. Local recurrence of sclerosing mucoepidermoid carcinoma with. Mucoepidermoid carcinoma is a malignant epithelial tumour of the salivary glands. Mucoepidermoid carcinoma mec is the most common salivary gland malignancy in children and adults, and the most common malignancy of the major and. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. We report the case of a 72yearold malay female after presentation with sore throat, fever and odynophagia, was diagnosed with mucoepidermoid. Jun 18, 20 mucoepidermoid carcinoma is a type of cancer of the salivary glands.
June 2017 includes ptnm requirements from the 8th edition, ajcc staging manual. Mucoepidermoid carcinoma of the soft palate salivary gland. Mec constitutes 310% of all tumours of major salivary glands and 1015% of tumours of minor salivary glands. Salivary gland mucoepidermoid carcinoma is a clinically, morphologically and genetically heterogeneous entity. The purpose of this study was to evaluate the clinical outcomes of mec of minor salivary glands in a group of 16 patients, who were treated in our. Despite of its relatively low incidence, the clinical behavior of mec differs tremendously, from slow growing indolent tumor with a generally good prognosis to aggressive tumor accompanied with distant metastasis and causing high mortality. Salivary gland cancer is diagnosed in 23 individuals per 100,000 people each year, and 3035% of these are mucoepidermoid carcinomas. Mucoepidermoid carcinoma in a salivary duct cyst of the. In such an instance, in2 type cells described by kawahara et al. Review of the major and minor salivary glands, part 2.
Mucoepidermoid carcinoma mec is considered the most common malignant salivary gland tumour. Healey wv, perzin kh, smith l 1970 mucoepidermoid carcinoma of salivary gland origin. Carcinoma, highgrade mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma. Mucoepidermoid carcinoma is the most common malignant, locally invasive tumour of the salivary glands and accounts for approximately 35% of all malignancies of the major and minor salivary glands. The mucoepidermoid carcinomas mec represent about 5% of all tumors in the salivary glands. Sixty patients with mucoepidermoid carcinoma of salivary gland origin were studied. Multidisciplinary management of salivary gland cancers.
Cords, sheets and clusters of mucous, squamous, intermediate and clear cells. The pathologic findings and the clinical course were examined separately and then correlated. Mucoepidermoid carcinoma of major and minor salivary glands. Salivary gland carcinomas are notoriously resistant to therapy and no standard of care exists. Oct 15, 2008 mucoepidermoid carcinoma mec is the most common malignancy of the major and minor salivary glands, comprising 34% of salivary gland malignancies. The establishment and description of mucoepidermoid carcinoma mec as a distinct salivary gland tumor was originally credited to stewart et al. Mucicarmine staining is one stain used by pathologist for detection. To date, no definitive therapeutic approach can compensate the impairment of salivary glands, and treatment are purely symptomatic. Physiology, pathology and regeneration of salivary glands. In 1953, foot and frazell named these tumors as mec. Prior reports noted histological grade and tumor stage as consistently important prognostic factors. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland. Mucoepidermoid carcinoma of the salivary glands springerlink.
Herein, we report clinical and radiological findings of a. A combination of surgery, chemotherapy, and radiation therapy are used to treat mucoepidermoid carcinoma of salivary gland. Mucoepidermoid carcinoma of the salivary glands i write from. Systemic therapy for recurrent or metastatic salivary gland. Epidemiologic profile of salivary gland neoplasms bjorl. Patients diagnosed as mucoepidermoid carcinoma of the salivary gland were eligible for analysis. Mucoepidermoid carcinoma of buccal mucosa bmj case reports. Presentation with synchronous salivary gland tumors is rare, with the most typical combination being warthins tumor and pleomorphic adenoma of the parotid. The criteria used to classify the lesions are discussed, and pathologic features are illustrated. It is an unusual type of a tumour in that it varies in its aggressiveness from a lowgrade slow growing to highgrade rapidly growing behaviour. Mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. Mucoepidermoid carcinoma mec is the most common malignancy of the major salivary glands. Mucoepidermoid carcinoma mec of the salivary gland is a rare entity. The fine anatomical and histological details will be covered in.
Lowgrade mucoepidermoid carcinoma of the lacrimal gland. Mucoepidermoid carcinoma is more frequent in females, occurs in the fifth decade of life and is usually found in. Mucoepidermoid carcinoma is a malignant epithelial tumour of glandular tissue, usually of the major salivary glands. Salivary gland anatomy n parotid gland n submandibular gland n sublingual gland n minor glands it is not our intent to cover anatomy during this course. Mucoepidermoid carcinoma mec is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor. Systemic therapy for recurrent or metastatic salivary. Intermediatedor highgrade mucoepidermoid carcinoma should be considered when tumors predominantly consist of squamous cells, especially in major salivary glands, except with evident preexisting pleomorphic adenoma. Aug 14, 2019 mucoepidermoid carcinoma in children appears to follow a more favorable course with cure rates of 98100% ord 1994. The hospital records were retrospectively analyzed from october 2010 to january 2016. The pleomorphic adenoma is the most common benign tumor 86%, and the mucoepidermoid carcinoma is the most common malignant tumor.
Jul 27, 2010 mucoepidermoid carcinoma mec is the most frequent malignant tumour that originates in the major and minor salivary glands, and represents about one third of all malignant salivary gland tumours. Postoperative radiation therapy for parotid mucoepidermoid. Salivary glands are essential structures in the oral cavity. The treatment may also depend upon the stage, overall health, age, and grade of the tumor. Mucoepidermoid carcinoma is the most common malignant neoplasm observed in the major and minor salivary glands among children and adults and shows a wide, nearly uniform age distribution, with diminution in pediatric and geriatric life. Prognostic factors in mucoepidermoid carcinoma of the salivary glands. Presents as painless, slowgrowing mass that is firm or hard. If you continue browsing the site, you agree to the use of cookies on this website. Treatment and survival outcomes based on histologic grading. Local recurrence of sclerosing mucoepidermoid carcinoma. Sixtynine cases of mucoepidermoid carcinoma with a minimum of five years followup are presented. Prognostic factors in mucoepidermoid carcinoma of the. Epidemiology mucoepidermoid carcinomas are seen throughout all. The second most common minor salivary gland tumour 1240% globally is mucoepidermoid carcinoma.
It is an aggressive lesion and must be considered as a diagnosis hypothesis in the oral. The tumors are classified as either well, moderately, or poorly differentiated. Herein, we report clinical and radiological findings of. Mucoepidermoid carcinoma of the parotid gland, cancer 10. Salivary gland neoplasms constitute about 3% of all neoplasms of the head and neck. Locally advanced stage highgrade mucoepidermoid carcinoma of. The purpose of this study was to evaluate the clinical outcomes of mec of minor salivary glands in a group of 16 patients, who were treated in our clinic, and to discuss the management of this carcinoma. Salivary gland cancers are divided into those arising in major salivary glands the parotid glands followed by the submandibular glands and. The salivary glands are classified as major or minor. Protocol for the examination of specimens from patients with carcinomas of the major salivary glands. A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of these glands, greatly impacting the quality of life of patients. It is also the most common central salivary gland tumor of the jaws. Lowgrade mucoepidermoid carcinoma is another potential consideration in the differential diagnosis of masc because both tumors can have a.
Mucoepidermoid carcinoma of the salivary glands i write. Mucoepidermoid carcinoma of the minor salivary glands core. Mucoepidermoid carcinoma is a tumor that usually occurs in the salivary glands. Mucoepidermoid carcinoma is the most frequent malignant tumor of the salivary glands in children. Diseasespecific and recurrence free survival were stratified by tumor. The most common location of lec is the nasopharynx. Occasional focal sebaceous cells, goblet type cells, oncocytic change, inflammatory reaction to extravasated mucin or keratin.
Mucoepidermoid carcinoma that originated from the lacrimal gland is exceedingly rare in teenage patients, with only a few cases reported. Siegmar reinert, in maxillofacial surgery third edition, 2017. Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. All patients received surgery as the primary treatment modality with or. In 1895, volkman described these tumors for first time. Histocytologic grading of mucoepidermoid carcinoma of. Pdf mucoepidermoid carcinoma mec is the most common malignant neoplasm of the major salivary glands, accounting for 15. Spiro rh, huvos ag, berk r, strong ew 1978 mucoepidermoid carcinoma of salivary gland origin. Mucoepidermoid carcinoma of salivary glands radiology. Pdf mucoepidermoid carcinoma is a malignant epithelial tumour of glandular tissue, usually of the major salivary glands. The fine anatomical and histological details will be covered in other courses. Introduction to salivary glands university of michigan. To analyze the patterns of failure and factors affecting recurrence and overall survival in mucoepidermoid carcinoma of the salivary gland.
Mucoepidermoid carcinoma an overview sciencedirect topics. Outcomes of postoperative concurrent chemoradiotherapy for. However, you should know the locations and characteristics of the salivary glands. Salivary gland cancers are rare and represent approximately 5% of all head and neck cancers and only 0. The most common malignant neoplasms include adenoid cystic carcinoma acc, mucoepidermoid carcinoma, and the malignant mixed tumors. Cetuximab in the treatment of metastatic mucoepidermoid. Mucoepidermoid carcinoma genetic and rare diseases. Lymphoepithelial carcinoma lec is an uncommon malignant tumor composed of undifferentiated malignant epithelial cells with characteristic lymphoid stroma. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The age of the patients ranged between 7 and 84 years. The histologic picture confirmed that the tumor was mec of parotid gland. Salivary gland tumours comprise almost 5% of head and neck malignancies. Newly described salivary gland tumors modern pathology nature.
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